puaspaisosoktara gedanghaseumgandosle

Jambuatah gedangburak jsalapa soekyyghhds

follow-up analysis provides additional support for the neoadjuvant therapy paradigm by showing that adjuvant T-DM1 also provided a significant improvement in overall survival and no evidence of long-term safety issues,” wrote KATHERINE investigators in The New England Journal of Medicine.

Patients enrolled in the phase 3, open-label trial continued to see an improvement in invasive disease-free survival with T-DM1 vs trastuzumab at a median follow-up of 8.4 years (unstratified HR = 0.54; 95% CI, 0.44-0.66). Particularly, 19.7% of patients in the T-DM1 group and 32.2% of patients in the trastuzumab group experienced invasive disease events or death.

Seven-year invasive disease-free survival was achieved in 80.8% of patients treated with T-DM1 and 67.1% of patients on trastuzumab (difference, 13.7 percentage points).

The trial included patients with HER2-positive early breast cancer who had received neoadjuvant treatment, which included a taxane-based chemotherapy and/or trastuzumab, and had residual invasive cancer in the breast or resected axillary nodes. Patients were randomly assigned to receive either T-DM1 (n = 743) or trastuzumab (n = 743). Patients were stratified by clinical stage, hormone-receptor status, preoperative HER2-directed therapy, and pathological nodal status after neoadjuvant therapy.

T-DM1 significantly reduced the risk for death compared with trastuzumab (unstratified HR = 0.66; 95% CI, 0.51-0.87; P = .003). Seven-year overall survival for the T-DM1 and trastuzumab groups were 89.1% and 84.4%, respectively (difference, 4.7 percentage points). As of the trial’s cutoff date of October 5, 2023, 70.1% of patients assigned T-DM1 and 62.0% of patients assigned trastuzumab were alive and still in the trial.

https://www.metooo.io/e/xem-phim-lau-nu-hon-bac-ty-full-hd-cam-vietsub-mien-phi

https://www.metooo.io/e/xem-phim-lau-nha-gia-tien-full-hd-cam-vietsub-mien-phi

https://www.metooo.io/e/xem-phim-lau-bo-tu-bao-thu-full-hd-cam-vietsub-mien-phi

https://www.metooo.io/e/xem-phim-lau-404-chay-ngay-di-full-hd-cam-vietsub-mien-phi

https://www.metooo.io/e/xem-phim-lau-rider-giao-hang-cho-ma-full-hd-cam-vietsub-mien-phi

https://www.metooo.io/e/xem-phim-lau-quy-nhap-trang-full-hd-cam-vietsub-mien-phi

https://www.metooo.io/e/xem-phim-lau-yeu-nham-ban-than-full-hd-cam-vietsub-mien-phi

https://www.metooo.io/e/xem-phim-lau-den-am-hon-full-hd-cam-vietsub-mien-phi

https://www.metooo.io/e/xem-phim-lau-dai-chien-nguoi-khong-lo-lan-tan-cong-cuoi-cung-full-hd-cam-vietsub

https://www.metooo.io/e/xem-phim-lau-sat-thu-vo-cung-cuc-hai-full-hd-cam-vietsub-mien-phi

https://www.metooo.io/e/phim-lau-sat-thu-vo-cung-cuc-hai-full-hd-vietsub-mien-phi-online

https://www.metooo.io/e/xem-phim-lau-ho-tu-than-full-hd-cam-vietsub-mien-phi